How can a clyster containing 500 mg metronidazole, 200 mg lidocaine HCl, 16 g TMF carbomer gel, and aqua conservans up to 100 ml be optimized for a patient with anastomotic leakage after transanal resection of rectal tumors, specifically regarding the solubility of metronidazole, the need for additional excipients, and the possibility of extending the shelf life to 6 months despite guidelines from the 2010 Pharmaceutical Journal for Belgium suggesting a 1-month limit for non-validated aqueous solutions?

How do you calculate the amount of elemental phosphorus per ml in a solution prepared for a neonatal patient containing 3.4 g of phosphoric acid BF5 and 4.8 g of Na2HPO4.2H2O in water up to 100 ml?

Why must the carbomer gel be anhydrous for the incorporation of flufenamic acid, given that processing flufenamic acid with an Unguator in a non-anhydrous carbomer gel also does not result in precipitation?

A dermatologist prescribes 14g resorcinol, 14g salicylic acid, 14g lactic acid, and antiseptic alcohol up to 100ml; is it possible to make this suspension more stable?

How much glucose or glycerol must be added to obtain isotonic Argyrol 0.5% nasal drops?

Is the reasoning correct that betamethasone dipropionate and valerate esters migrate to the interface in two-phase systems (o/w and w/o emulsions), given that betamethasone dipropionate is nearly insoluble in water (0.7 mg/L) but soluble in lipophilic solvents, and could this positioning explain both the rearrangement of betamethasone-17-valerate to the less active 21-valerate at pH > 6 and ester hydrolysis at pH > 7, despite the aqueous phase typically being buffered to pH 4-5 in most corticosteroid creams for stability?

What is the formulation for an oral Lugol's solution used for thyroid blockade during a nuclear medicine examination?