What alternative can be used for Adeps solidus, Novata B, given that many suppository masses are currently unavailable, for the preparation of suppositories containing caffeine, paracetamol, and codeine phosphate, noting that the melting point of Novata B is 35.5 °C?

What is the best procedure to stabilize a cold cream preparation containing 0.1% betamethasone, 10% liquor carbonis detergens (LCD), and 2% urea, given that the cream consistently breaks when LCD exceeds 5% even after adding 400mg/100g of hypromellose?

Is Carbopol 980 suitable for internal use in a budesonide suspension for the esophagus, given that the hospital pharmacist suggested it can be prepared with carbomer gel TMF like rectal suspensions, despite the packaging only specifying external use?

What is the best way to prepare progesterone 400 mg ovules considering that a hydrophilic base of 3 parts PEG 400 and 2 parts PEG 6000 was previously used, but APB-NF VI PEG 6000 is currently unavailable?

What are the recommended concentrations for eye drops containing azithromycin, cefuroxime, or ceftriaxone as the active ingredient, given that an ophthalmologist has not specified the concentration and no information could be found in Martindale?

Is it possible to make an officinal preparation of Zinolium (ZnSO4 gel) using a formula containing 1.78g ZnSO4.7Aqua, 2g Carbopol 980, 50mg Na-EDTA, 15g propylene glycol, 4.058g trometamol, and aqua conservans ad 100g, given that water separates from the gel whenever the dissolved zinc sulfate is added to either a self-prepared or a prefabricated carbomer gel (TMF composition)? Does this problem stem from an incompatibility between zinc sulfate and Carbopol, or is it caused by replacing triethanolamine with trometamol for neutralization, and is there a viable Carbopol-based alternative to the methylcellulose composition in the NF?

What are the stability problems of a solution containing 3 grams of Phenobarbital sodium and purified water up to 300 cc?