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Die Rezeptur‑Helpdesk enthält mehr als 1500 Fragen und Antworten zu verschiedenen galenischen Themen, alle bereitgestellt von Prof. R. Kinget.
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Is it a good choice to use Na-CMC or hydroxyethylcellulose for a lubricant, how many g/l should be used, and how can clumping or foaming be prevented during preparation?
Can Lidocaine HCl be combined with Maalox (aluminum oxide and magnesium hydroxide), does this result in the formation of a precipitate, and does the mixture retain its effectiveness?
Is salicylic acid permitted in cetomacrogol cream TMF despite the phenol group, considering that a trainee claims it is not allowed due to this group, yet it is approved in the ACA and Pannoc lists, and how should this be explained?
When preparing 20 capsules of 4 mg folic acid with a 5% overdose for a unit dose under 10 mg and a 10% compensation for water content (totaling 4.62 mg per capsule and 92.4 mg total), should the 1/10 trituration (e.g., 500 mg in 5 g diluent) also be compensated for water content (e.g., 550 mg in 5 g diluent), or would this result in double compensation since the calculation for the capsules already accounts for it?
What is the correct color and texture for a compounded cream containing 2.5 g hydroquinone, 36 mg tretinoin, and 50 mg dexamethasone in 50 g Beeler basis, given that a patient's Spanish specialty version is light gray/pink with a grainy texture, while a Belgian preparation (including antioxidants BHT and sodium metabisulfite) is light yellow and smooth, and could the specialty's appearance be due to hydroquinone discoloration from poor storage?
How can a stable, clear solution be prepared for a Dalacin lotion substitute containing 5 g salicylic acid, 600 mg clindamycin (as 712 mg phosphate), 6 g propylene glycol, 200 g purified water, and 120 g isopropyl alcohol, given that a precipitate forms which is suspected to be caused by the incompatible pH requirements of the acid and base components, and considering that the solution becomes clear after adding a small amount of base?
What are the stability problems of a solution containing 3 grams of Phenobarbital sodium and purified water up to 300 cc?
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